I have been using Xunit and Test Driven.Net for almost a year now. The Xunit unit testing framework is clean, concise and powerful. Test Drive.Net allows you to run most 3rd party unit testing frameworks from within Visual Studio.
I was a little worried that these tools would not work in VS2010 Beta 2 which I just installed, but thankfully they do work. However, you have to use keyboard short cut commands in VS2010 since command bar extensibility is not present.
Jamie, the author of TDD.Net has a post in which he explains how to setup the keyboard shortcuts. He also has a link to a .vsSettings file that will setup the shortcuts for you. All I can say is, outstanding work.